Drug reference

Nedocromil

Antihistamine · Anti-asthmatic

Also known as Nedocromil sodium

AntihistamineAnti-asthmatic

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

Can be used as normal during pregnancy.

FDA category + note

Mechanism

Nedocromil sodium is a chromone derivative that stabilizes mast cell membranes and inhibits degranulation, preventing the release of histamine, leukotrienes, and other inflammatory mediators from sensitized mast cells. It also appears to modulate chloride channel function on sensory nerves. Unlike bronchodilators, nedocromil has no direct smooth muscle relaxant activity and is effective only as prophylaxis when administered regularly before allergen or exercise exposure.

Indications

Prophylaxis of asthmaExercise-induced asthma (as an add-on therapy for patients already taking an ICS who are otherwise well controlled)allergic conjunctivitis

Dosing

Adult: BY INHALATION OF AEROSOL: Initially 4 mg 4 times a day, when control achieved may be possible to reduce to twice daily.
Pediatric: BY INHALATION OF AEROSOL: Child 5–17 years: Initially 4 mg 4 times a day, when control achieved may be possible to reduce to twice daily. Not licensed for use in children under 6 years.