Aminosalicylic Acid
Severe
Database
Clinical effect not specified
Source: DDInter
Drug reference
Prilocaine
Local Anesthetic · Anaesthesia
Also known as Prilocaine hydrochloride
Local AnestheticAnaesthesia
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
than either drug alone.
FDA category + note
Top interactionssee all 12 →
- Aminosalicylic AcidSevereDatabaseDDInter
- Amyl NitriteSevereDatabaseDDInter
- BenzocaineSevereDatabaseDDInter
- BupivacaineSevereDatabaseDDInter
Mechanism
Prilocaine hydrochloride is a local anaesthetic of low toxicity which is similar to lidocaine hydrochloride. It is an amide-type local anaesthetic.
Indications
Spinal anaesthesia (using hyperbaric solution)Premature ejaculation (in combination with Lidocaine)Intravenous regional blocksDentistrySuperficial anesthesia (in combination with lidocaine as EMLA)InfiltrationNerve blockIntravenous regional anaesthesia
Dosing
- Adult
- l INDICATIONS AND DOSE Premature ejaculation in men who meet all the following criteria: poor control over ejaculation, a history of premature ejaculation over the past 6 months, marked distress or interpersonal difficulty as a consequence of premature ejaculation, and an intravaginal ejaculatory latency time of less than two minutes ▶ BY MOUTH ▶ Adult: Initially 30 mg, to be taken approximately 1…
Pharmacokinetics
Protein binding
Binds extensively (55%–95%) to plasma proteins, particularly α1-acid glycoprotein.
Metabolism
Initial step is hydrolytic, forming o-toluidine metabolites.
Contraindications
- Known hypersensitivity to amide-type local anaesthetics
Side effects
Common
Hypersensitivity reactionsLess vasodilatory compared to lidocaineLower CNS toxicity compared to lidocaine
Serious
- Methemoglobinemia (consequence of metabolism of aromatic ring to o-toluidine; usually after dose of 8 mg/kg)
- Methaemoglobinaemia (due to a metabolite)
Pregnancy & lactation
Pregnancy
than either drug alone.
Drug interactions
Amyl Nitrite
Severe
Database
Clinical effect not specified
Source: DDInter
Benzocaine
Severe
Database
Clinical effect not specified
Source: DDInter
Bupivacaine
Severe
Database
Clinical effect not specified
Source: DDInter
Chloroquine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Dapsone
Severe
Database
Clinical effect not specified
Source: DDInter
Dibucaine
Severe
Database
Clinical effect not specified
Source: DDInter
Etidocaine
Severe
Database
Clinical effect not specified
Source: DDInter
Flutamide
Severe
Database
Clinical effect not specified
Source: DDInter
Isosorbide Dinitrate
Severe
Database
Clinical effect not specified
Source: DDInter
Isosorbide Mononitrate
Severe
Database
Clinical effect not specified
Source: DDInter
Levobupivacaine
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Other Local Anesthetic drugs
Ask House about Prilocaine
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Sources: KD Tripathi 7e, Goodman & Gilman 14e, BNF·Verified: 2026-05-13 · House clinical team