Procaine

Procaine is an ester-type local anesthetic that blocks voltage-gated sodium channels in nerve fibers, preventing action potential generation and propagation. As an ester, it is rapidly hydrolyzed by plasma cholinesterases to para-aminobenzoic acid (PABA) and diethylaminoethanol, giving it the shortest duration of action among injectable local anesthetics. The PABA metabolite can antagonize the antibacterial activity of sulfonamides and is responsible for the higher incidence of allergic reactions compared to amide-type anesthetics.

Adult

range of doses that are generally regarded as being suitable for adults. Complementary and alternative medicine Prescribing unlicensed medicines An increasing amount of information on complementary and alternative medicine is becoming available.…