Drug reference

Sparfloxacin

Fluoroquinolone · Antibiotic

FluoroquinoloneAntibiotic

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

12 major

incl. contraindicated

PREGNANCY

—

not curated

Top interactionssee all 12 →

AmiodaroneContraindicatedDatabaseDDInter
AbirateroneSevereDatabaseDDInter
AdenosineSevereDatabaseDDInter
AlfuzosinSevereDatabaseDDInter

Mechanism

Sparfloxacin, a fluoroquinolone antibiotic, targets bacterial DNA gyrase and topoisomerase IV. These enzymes are crucial for maintaining the supercoiling of bacterial DNA, which is essential for DNA replication and transcription. By inhibiting these enzymes, sparfloxacin disrupts bacterial DNA processes, leading to cell death.

Indications

pneumoniaexacerbations of chronic bronchitissinusitisother ENT infections

Dosing

Adult: though initially the same drugs had suppressed VES in these patients. It is possible that during transient episodes of SUBCLASS IA ischaemia, the intraventricular conduction slowing action of these drugs gets markedly accentuated resulting in VT and The subclass IA containing the oldest anti- VF.…

Side effects

Common

phototoxic reactions

Serious

Phototoxicity
QTc prolongation
Torsades de pointes
QTc interval prolongation (in 3% recipients)
fatal arrhythmias (with other Q-T prolonging drugs)

Drug interactions

Amiodarone

Contraindicated

Database

Increased risk of Torsades de Pointes (TdP), ventricular arrhythmias, and sudden cardiac death.

Avoid concomitant use. If no alternative exists and co-administration is absolutely necessary, continuous ECG monitoring and electrolyte correction are mandatory, but generally not recommended.

Source: DDInter

Abiraterone

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Adenosine

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Alfuzosin