Drug reference

Sulpiride

Atypical Antipsychotic · Antipsychotic

Also known as Sulpride

Atypical AntipsychoticAntipsychotic

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

Sulpiride acts as an antagonist with equivalent potency at dopamine D2 and D3 receptors. It also functions as an antagonist at 5-HT7 receptors, contributing to its antipsychotic effects.

Indications

PsychosesSchizophrenia

Dosing

Geriatric: Initial doses of antipsychotic drugs in elderly patients should be reduced (to half the adult dose or less), taking into account factors such as the patient’s weight, co-morbidity, and concomitant medication.

Side effects

Common

Reduced sedative effectsReduced antimuscarinic effectsReduced extrapyramidal effects

Serious

Extrapyramidal symptoms
Elevated prolactin levels
Tardive dyskinesia
Increased risk of mortality (in elderly patients with dementia)
Increased risk of stroke or transient ischaemic attack (in elderly patients with dementia)