Tazarotene

Tazarotene, a third-generation retinoid, exerts its effects on gene expression by activating retinoic acid receptors (RARs), which are members of the steroid receptor superfamily. Upon binding, RARs form heterodimers with retinoid X receptors (RXRs), which then bind to specific DNA sequences called retinoic acid–responsive elements (RAREs). This binding activates the transcription of genes whose products predominantly affect cellular differentiation and proliferation, leading to its therapeutic effects.

Adult

0.5-1 g given over 2-3 hours. More rapid infusion has been associated with increased rates of hypotension, electrolyte shifts, and. 0.5-2 mg/kg/day. 0.25-1 mg/kg/day. 0.5-1 mg/kg/day. 300 mg/m2/day

• Application to the face
• Application in flexures
• Inflammatory forms of psoriasis
• During an inflammatory phase of psoriasis
• If significant irritation occurs
• Pregnancy (teratogenic)