Drug reference

Adapalene

Retinoid · Anticomedonal

RetinoidAnticomedonal

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

1 major

SEVERE in our sources

PREGNANCY

Contraindicated in women who are pregnant or planning pregnancy; women of childbearing potential must use effective contraception (progestogen-only contraceptives not considered effective).

FDA category + note

Top interactionssee all 2 →

Aminolevulinic AcidSevereDatabaseDDInter

Mechanism

Adapalene, a third-generation retinoid, selectively binds to nuclear retinoic acid receptors (RARs), particularly RAR-gamma. This binding activates specific DNA sequences (RAREs), modulating gene expression involved in cellular differentiation and keratinization of follicular epithelial cells. The resulting normalization of follicular keratinization, decreased keratin and sebum production, and anti-inflammatory effects suppress comedone formation and reduce inflammatory lesions in acne.

Indications

Comedones in mild to moderate acneInflammatory lesions in mild to moderate acneAcne vulgaris

Dosing

Adult: Apply once daily, to be applied in the evening to the skin.
Pediatric: Child 12–17 years: Apply once daily, to be applied in the evening to the skin.

Contraindications

Not for use by women who are pregnant or planning pregnancy, or women of childbearing potential unless effective contraception is used (based on combination product Epiduo which contains Adapalene)

Side effects

Common

Less irritating than tretinoin

Pregnancy & lactation

Pregnancy

Contraindicated in women who are pregnant or planning pregnancy; women of childbearing potential must use effective contraception (progestogen-only contraceptives not considered effective).