Drug reference
Adapalene + Benzoyl Peroxide
Retinoid · Anti-acne agent
Also known as Epiduo, Epiduo Forte
RetinoidAnti-acne agent
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
Avoid.
FDA category + note
Mechanism
Adapalene, a naphthoic acid derivative, structurally and functionally resembles retinoic acid. Retinoic acid influences keratinization and desquamation. Its prolonged use promotes dermal collagen synthesis, new blood vessel formation, and epidermal thickening. Specific mechanism for benzoyl peroxide is not provided in the excerpts.
Indications
Acne vulgarisMild to moderate facial acne (restricted when monotherapy with benzoyl peroxide or adapalene is inappropriate)
Dosing
- Adult
- Apply once daily, to be applied thinly in the evening
- Pediatric
- Child 9–17 years: Apply once daily, to be applied thinly in the evening
Contraindications
- Pregnancy
- Females of childbearing age not using effective contraception
- Accumulation in angles of the nose
- Contact with eyes
- Contact with nostrils
- Contact with mouth
- Contact with mucous membranes
- Contact with eczematous skin
- Contact with broken skin
- Contact with sunburned skin
- Exposure to UV light (including sunlight, solariums)
- Severe acne involving large areas
Pregnancy & lactation
Pregnancy
Avoid.
Lactation
Amount of drug in milk probably too small to be harmful; ensure infant does not come in contact with treated areas.
Related guidelines
Other Retinoid drugs
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Sources: BNF·Verified: 2026-05-10 · House clinical team