Cefadroxil

Cefadroxil, a cephalosporin antibiotic, exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. It covalently binds to and inactivates penicillin-binding proteins (PBPs), which are transpeptidases crucial for the cross-linking of peptidoglycan strands in the bacterial cell wall. This disruption leads to a defective, osmotically unstable cell wall, ultimately causing bacterial lysis and cell death.

Adult

For susceptible infections: 0.5–1 g twice daily by mouth. For skin infections, soft-tissue infections, or uncomplicated urinary-tract infections: 1 g daily by mouth.

Pediatric

Child 6–17 years (body-weight up to 40 kg) for susceptible infections: 0.5 g twice daily by mouth. Child 6–17 years (body-weight 40 kg and above) for susceptible infections: 0.5–1 g twice daily by mouth. Child 6–17 years (body-weight 40 kg and above) for skin infections, soft-tissue infections, or uncomplicated urinary-tract infections: 1 g once daily by mouth.

Renal adjustment

In adults, 1 g initially, then 500 mg every 12 hours if eGFR 26–50 mL/minute/1.73 m2. 1 g initially, then 500 mg every 24 hours if eGFR 11–26 mL/minute/1.73 m2. 1 g initially, then 500 mg every 36 hours if eGFR less than 11 mL/minute/1.73 m2. In children, reduce dose if estimated glomerular filtration rate less than 50 mL/minute/1.73 m2.

• Patients with a history of immediate hypersensitivity to penicillin, if a suitable alternative antibacterial is not available