Drug reference

Cefdinir

Cephalosporin · Antibiotic

Also known as OMNICEF

CephalosporinAntibiotic

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

FDA category + note

Mechanism

Cephalosporins, like penicillins, inhibit bacterial cell wall synthesis by targeting proteins on the inner membrane. While generally more resistant to many β-lactamases than first-generation agents, third-generation cephalosporins are susceptible to hydrolysis by inducible, chromosomally encoded (type I) β-lactamases.

Indications

EnterobacteriaceaeSerratiaNeisseria gonorrhoeaeS. aureus (activity comparable to first-generation agents)Streptococcus pneumoniae (activity comparable to first-generation agents)Streptococcus pyogenes (activity comparable to first-generation agents)Community-acquired pneumoniaMeningitisUrinary tract infectionsStreptococcal endocarditisGonorrheaSevere Lyme diseaseMany beta-lactamase producing organisms (good activity)Respiratory pathogens including gram-positive cocci (susceptible)PneumoniaAcute exacerbations of chronic bronchitisENT infectionsSkin infections

Dosing

Adult: 300 mg orally every 12 hours or 600 mg orally every 24 hours
Renal adjustment: Dosage should be altered in patients with renal insufficiency as cephalosporins are primarily excreted by the kidney.
Max dose: 600 mg daily