Domperidone
Contraindicated
Database
Increased risk of QT prolongation and Torsades de Pointes (TdP)
Concomitant use is contraindicated. Avoid co-administration.
Drug reference
Citalopram
SSRI · Antidepressant
SSRIAntidepressant
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
incl. contraindicated
PREGNANCY
Persistent pulmonary hypertension in the newborn has been reported.
FDA category + note
Top interactionssee all 12 →
- DomperidoneContraindicatedDatabase
- AbarelixSevereDatabaseDDInter
- AbirateroneSevereDatabaseDDInter
- AdenosineSevereDatabaseDDInter
Mechanism
Citalopram is a Selective Serotonin Reuptake Inhibitor (SSRI).
Indications
Depressive illnessMajor depressive disorderObsessive-compulsive disorderPanic disorderGeneralized anxiety disorderFibromyalgiaNeuropathic painAnxietymajor depressiongeneralized anxietysocial anxietyPTSDpremenstrual dysphoric syndromepreventing vasovagal symptoms in postmenopausal womenAgitation in AD (BPSD)Depression in HDHot flashes in women
Dosing
- Adult
- Lower dose for S-citalopram (escitalopram)
- Hepatic adjustment
- For tablets, initial dose of 10 mg daily for the first two weeks in mild to moderate impairment; dose may be increased to max. 20 mg daily. Use with extra caution and careful dose titration in severe impairment. For oral drops, initial dose of 8 mg daily.
Pharmacokinetics
Half-life
36 hours
Bioavailability
Rac: 80 ± 13%
Protein binding
Rac: 80%
Metabolism
hepatic (CYP3A4, CYP2C19)
Excretion
Rac: 10.5 ± 1.4%
Side effects
Common
Sexual dysfunctioninsomniaincreased anxietyirritabilitydecreased libidoerectile dysfunctionanorgasmiaejaculatory delaynauseadiarrheaemesisdullness of intellectual abilitiesconcentration issuesless side effects for S-citalopram (escitalopram)
Serious
- Serotonin syndrome
- serotonin syndrome (with MAOIs)
- suicidal ideation or behavior (black-box warning in children and adolescents)
- discontinuation syndrome
- persistent pulmonary hypertension in newborns
Pregnancy & lactation
Pregnancy
Persistent pulmonary hypertension in the newborn has been reported.
Drug interactions
Abarelix
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Abiraterone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Adenosine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Alfentanil
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Alimemazine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Almotriptan
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amisulpride
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Anagrelide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Apalutamide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Apomorphine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Arsenic Trioxide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Related guidelines
Other SSRI drugs
Ask House about Citalopram
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e, Harrison 22e, Katzung·Verified: 2026-05-10 · House clinical team