Pimozide
Contraindicated
Database
Increased risk of QT prolongation and ventricular arrhythmias
Concomitant use is contraindicated.
Source: DDInter
Drug reference
Paroxetine
SSRI · Antidepressant, Anxiolytic
SSRIAntidepressant, Anxiolytic
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
11 major
incl. contraindicated
PREGNANCY
—
not curated
Top interactionssee all 11 →
- PimozideContraindicatedDatabaseDDInter
- ThioridazineContraindicatedDatabaseDDInter
- Aceclofenac + ParacetamolSevereTextbookKDT 7e
- AceclofenacSevereTextbookKDT 7e
Mechanism
Paroxetine is a Selective Serotonin Reuptake Inhibitor (SSRI).
Indications
AnxietyAnxiety disordersObsessive-compulsive disorderMajor depressive disorderPanic disorderGeneralized anxiety disorderFibromyalgiaNeuropathic painmajor depressiongeneralized anxietysocial anxietyPTSDpremenstrual dysphoric syndromepreventing vasovagal symptoms in postmenopausal womenDepression in terminally ill patients (with prognosis of several months or longer)Anxiety and sleeplessness (when they are major symptoms, due to sedating properties)Depression in cancer patients
Dosing
- Adult
- effective dose and for the shortest time possible, with a regular review at least every 6 weeks. h In patients who have dementia with Lewy bodies or Parkinson’s disease dementia, antipsychotic drugs can worsen the motor features of the condition, and in some cases cause severe antipsychotic sensitivity reactions. See also management of psychotic symptoms in Parkinson’s disease p. 429.…
Pharmacokinetics
Half-life
17 hours
Bioavailability
Dose dependent
Protein binding
95%
Metabolism
hepatic (CYP2D6)
Excretion
<2%
Contraindications
- Minimize use in patients with dementia due to increased antimuscarinic burden and potential for cognitive impairment.
Side effects
Common
Sexual dysfunctioninsomniaincreased anxietyirritabilitydecreased libidoerectile dysfunction (more prominent)anorgasmia (more prominent)ejaculatory delay (more prominent)nauseadiarrheaemesisdullness of intellectual abilitiesconcentration issuescomparatively few
Serious
- Serotonin syndrome
- serotonin syndrome (with MAOIs)
- suicidal ideation or behavior (black-box warning in children and adolescents)
- discontinuation syndrome (most intense)
- congenital cardiac malformations (when administered in first trimester of pregnancy)
- persistent pulmonary hypertension in newborns
Drug interactions
Thioridazine
Contraindicated
Database
Increased risk of serious ventricular arrhythmias (e.g., Torsades de Pointes) and sudden death.
Concomitant use is contraindicated. A washout period is required when switching between these drugs.
Source: DDInter
Aceclofenac + Paracetamol
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Aceclofenac
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Capsaicin
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Diclofenac + Paracetamol
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Etoricoxib
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Ibuprofen + Paracetamol
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Nepafenac
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Paracetamol + Caffeine + Phenylephrine
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Paracetamol
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
1 additional unreviewed or low-confidence interaction hidden because their provenance or source detail is insufficient.
Related guidelines
Other SSRI drugs
Ask House about Paroxetine
Continue into a citation-backed clinical answer with the drug context already attached.
Textbook-sourced·Sources: Goodman & Gilman 14e, Harrison 22e, BNF·Updated: 2026-05-13