Aceclofenac + Paracetamol
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Drug reference
Fluvoxamine
SSRI · Antidepressant
Also known as Fluvoxamine maleate, Faverin
SSRIAntidepressant
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- Aceclofenac + ParacetamolSevereTextbookKDT 7e
- AceclofenacSevereTextbookKDT 7e
- CapsaicinSevereTextbookKDT 7e
- Diclofenac + ParacetamolSevereTextbookKDT 7e
Mechanism
Fluvoxamine selectively inhibits serotonin reuptake by blocking the serotonin transporter (SERT), increasing synaptic 5-HT availability. It is unique among SSRIs in having significant sigma-1 receptor agonist activity, which may contribute additional anxiolytic and neuroprotective effects distinct from serotonergic mechanisms. Fluvoxamine is a potent inhibitor of CYP1A2 and CYP2C19 (and moderate inhibitor of CYP3A4), creating substantial drug interaction potential with theophylline, warfarin, and benzodiazepines.
Indications
Depressive illnessObsessive-compulsive disorderAntidepressantAnxietyPanic disorderFibromyalgiaNeuropathic pain
Dosing
- Adult
- For depressive illness: Initially 50–100 mg daily, taken in the evening. Increase gradually up to 300 mg daily if necessary; doses over 150 mg daily are given in divided doses. Maintenance dose is 100 mg daily. For obsessive-compulsive disorder: Initially 50 mg daily, taken in the evening.…
- Renal adjustment
- Start with low dose.
- Hepatic adjustment
- Manufacturer advises low initial dose.
- Max dose
- 300 mg daily
Pharmacokinetics
Half-life
18 hours
Metabolism
hepatic (CYP2D6, CYP1A2, CYP3A4, CYP2C9)
Contraindications
- Breastfeeding
Side effects
Common
Sexual dysfunctioninsomniaincreased anxietyirritabilitydecreased libidoerectile dysfunctionanorgasmiaejaculatory delaynauseadiarrheaemesisdullness of intellectual abilitiesconcentration issues
Serious
- Hepatic function abnormal (discontinue)
- Bone fracture
- Glaucoma
- Neuroleptic malignant-like syndrome
- Neonatal withdrawal syndrome
- Serotonin syndrome
- serotonin syndrome (with MAOIs)
- suicidal ideation or behavior (black-box warning in children and adolescents)
- discontinuation syndrome
- persistent pulmonary hypertension in newborns
Pregnancy & lactation
Lactation
Present in milk—avoid.
Drug interactions
Aceclofenac
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Capsaicin
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Diclofenac + Paracetamol
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Etoricoxib
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Ibuprofen + Paracetamol
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Nepafenac
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Paracetamol
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Paracetamol + Caffeine + Phenylephrine
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Tenoxicam
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Alfentanil
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Almotriptan
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Related guidelines
Other SSRI drugs
Ask House about Fluvoxamine
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, Katzung, BNF·Verified: 2026-05-13 · House clinical team