Aceclofenac + Paracetamol
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Drug reference
Dapoxetine
SSRI · Treatment of Premature Ejaculation
SSRITreatment of Premature Ejaculation
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- Aceclofenac + ParacetamolSevereTextbookKDT 7e
- AceclofenacSevereTextbookKDT 7e
- AspirinSevereTextbookKDT 7e
- BromfenacSevereTextbookKDT 7e
Mechanism
Dapoxetine is a short-acting selective serotonin re-uptake inhibitor. It works by blocking the reuptake of serotonin in the synaptic cleft, thereby increasing the concentration of serotonin. This leads to receptor desensitization over time, which contributes to its effect of delaying ejaculation.
Indications
Premature ejaculation in men who meet all the following criteria: poor control over ejaculation, a history of premature ejaculationUsed when required for premature ejaculation (not continuous daily use)
Dosing
- Adult
- When required (not continuous daily use)
Pharmacokinetics
Onset
Ejaculation delay may start a few days after the start of treatment, but it is more evident after 1 to 2 weeks
Duration
short-acting
Side effects
Serious
- Suicidal ideation (particularly when associated with depressive disorder)
Drug interactions
Aceclofenac
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Aspirin
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Bromfenac
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Capsaicin
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Choline Salicylate
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Clopidogrel
Severe
Textbook
Increased bleeding risk.
Exercise extra caution and monitor for signs of bleeding.
Source: G&G 14e
Diclofenac
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Diclofenac + Paracetamol
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Etodolac
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Etoricoxib
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Flurbiprofen
Severe
Textbook
Increased risk of gastrointestinal bleed.
Monitor for bleeding; consider gastroprotective agents or alternative analgesics.
Source: KDT 7e
Related guidelines
Other SSRI drugs
Ask House about Dapoxetine
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: BNF·Verified: 2026-05-10 · House clinical team