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Drug reference

Desoximetasone

Corticosteroid · Dermatologic Agent

Also known as TOPICORT, Topicort L.P.

CorticosteroidDermatologic Agent
CDSCO approvedSchedule H
EXCRETION
not curated
INTERACTIONS
none in our sources
PREGNANCY
not curated

Mechanism

Desoximetasone, as a glucocorticoid, inhibits the immune system and inflammatory responses. It exerts its therapeutic effects by its multifaceted action on various cellular and molecular components involved in inflammation. This includes suppressing immune cell function and reducing the production of inflammatory mediators.

Dosing

Adult
Corticosteroids are only minimally absorbed following application to normal skin; for example, approximately 1% of a dose of hydrocortisone solution applied to the ventral forearm is absorbed. Long­term occlusion with an impermeable film such as plastic wrap is an effective method of enhancing penetration, yielding a 10­fold increase in absorption.…

Pharmacokinetics

Bioavailability
Minimally absorbed following topical application to normal skin (e.g., approximately 1% of hydrocortisone solution applied to the ventral forearm is absorbed)

Contraindications

  • Known infections of some consequence (administer only if absolutely necessary and concomitantly with appropriate antimicrobial/antifungal therapy)

Side effects

Common
HyperglycemiaGlycosuria
Serious
  • Increased susceptibility to infection
  • Reactivation of latent tuberculosis

Other Corticosteroid drugs

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Sources: Katzung·Verified: 2026-05-13 · House clinical team