Drug reference
Desoximetasone
Corticosteroid · Dermatologic Agent
Also known as TOPICORT, Topicort L.P.
CorticosteroidDermatologic Agent
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
Desoximetasone, as a glucocorticoid, inhibits the immune system and inflammatory responses. It exerts its therapeutic effects by its multifaceted action on various cellular and molecular components involved in inflammation. This includes suppressing immune cell function and reducing the production of inflammatory mediators.
Dosing
- Adult
- Corticosteroids are only minimally absorbed following application to normal skin; for example, approximately 1% of a dose of hydrocortisone solution applied to the ventral forearm is absorbed. Longterm occlusion with an impermeable film such as plastic wrap is an effective method of enhancing penetration, yielding a 10fold increase in absorption.…
Pharmacokinetics
Bioavailability
Minimally absorbed following topical application to normal skin (e.g., approximately 1% of hydrocortisone solution applied to the ventral forearm is absorbed)
Contraindications
- Known infections of some consequence (administer only if absolutely necessary and concomitantly with appropriate antimicrobial/antifungal therapy)
Side effects
Common
HyperglycemiaGlycosuria
Serious
- Increased susceptibility to infection
- Reactivation of latent tuberculosis
Other Corticosteroid drugs
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Sources: Katzung·Verified: 2026-05-13 · House clinical team