Drug reference

Fluocinolone

Corticosteroid · Ophthalmic Anti-inflammatory

Also known as Fluocinolone acetonide, Iluvien®

CorticosteroidOphthalmic Anti-inflammatory

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

Manufacturer advises avoid unless potential benefit outweighs risk—no information available.

FDA category + note

Mechanism

Fluocinolone, as a corticosteroid, exerts its effects by binding to intracellular glucocorticoid receptors, modulating gene expression to produce anti-inflammatory and immunosuppressive effects. It inhibits the release of inflammatory mediators and suppresses the migration of leukocytes.

Indications

Treatment of visual impairment associated with chronic diabetic macular oedema which is insufficiently responsive to available therapies (specialist use only)Prevention of relapse in recurrent non-infectious uveitis affecting the posterior segment of the eye (specialist use only)

Dosing

Adult: 190 micrograms, to be administered into the affected eye by intravitreal injection; concurrent administration to both eyes not recommended. For further information on pre-treatment, administration and repeat dosing, consult product literature.