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glucocorticoids

Corticosteroid · Anti-inflammatory, Immunosuppressant, Hypercalcaemia treatment

CorticosteroidAnti-inflammatory, Immunosuppressant, Hypercalcaemia treatment
CDSCO approved
EXCRETION
not curated
INTERACTIONS
12 major
incl. contraindicated
PREGNANCY
not curated
Top interactionssee all 12
  • MifepristoneContraindicatedTextbookG&G 14e
  • Aceclofenac + ParacetamolSevereTextbookG&G 14e · p1013
  • AceclofenacSevereTextbookG&G 14e · p1013
  • AspirinSevereTextbookG&G 14e · p1013

Mechanism

Enhance calcium excretion and decrease calcium absorption.

Indications

Adjuvant role in hypercalcaemia due to lymphoma, myeloma, leukaemia, carcinoma breast, etc.

Dosing

Adult
High doses of prednisolone (and others).

Pharmacokinetics

Onset
Slow to act, takes 1–2 weeks.

Drug interactions

Mifepristone
Contraindicated
Textbook

Increases both corticotropin and adrenal steroid levels in the plasma, and at high doses, can result in adrenal insufficiency.

Women receiving chronic glucocorticoid therapy should not be given mifepristone due to its antiglucocorticoid activity. High doses of mifepristone can lead to adrenal insufficiency.

Source: G&G 14e

Aceclofenac + Paracetamol
Severe
Textbook

Increased risk of gastritis, ulcer formation, and gastrointestinal bleeding. Glucocorticoids can also mask the symptoms of serious gastrointestinal disease, increasing the risk of perforated sigmoid diverticular abscesses.

Not explicitly stated, but implies caution and awareness of increased risk.

Source: G&G 14e · p1013

Aceclofenac
Severe
Textbook

Increased risk of gastritis, ulcer formation, and gastrointestinal bleeding. Glucocorticoids can also mask the symptoms of serious gastrointestinal disease, increasing the risk of perforated sigmoid diverticular abscesses.

Not explicitly stated, but implies caution and awareness of increased risk.

Source: G&G 14e · p1013

Aspirin
Severe
Textbook

Increased risk of gastritis, ulcer formation, and gastrointestinal bleeding. Glucocorticoids can also mask the symptoms of serious gastrointestinal disease, increasing the risk of perforated sigmoid diverticular abscesses.

Not explicitly stated, but implies caution and awareness of increased risk.

Source: G&G 14e · p1013

Bromfenac
Severe
Textbook

Increased risk of gastritis, ulcer formation, and gastrointestinal bleeding. Glucocorticoids can also mask the symptoms of serious gastrointestinal disease, increasing the risk of perforated sigmoid diverticular abscesses.

Not explicitly stated, but implies caution and awareness of increased risk.

Source: G&G 14e · p1013

Capsaicin
Severe
Textbook

Increased risk of gastritis, ulcer formation, and gastrointestinal bleeding. Glucocorticoids can also mask the symptoms of serious gastrointestinal disease, increasing the risk of perforated sigmoid diverticular abscesses.

Not explicitly stated, but implies caution and awareness of increased risk.

Source: G&G 14e · p1013

Choline Salicylate
Severe
Textbook

Increased risk of gastritis, ulcer formation, and gastrointestinal bleeding. Glucocorticoids can also mask the symptoms of serious gastrointestinal disease, increasing the risk of perforated sigmoid diverticular abscesses.

Not explicitly stated, but implies caution and awareness of increased risk.

Source: G&G 14e · p1013

Diclofenac + Paracetamol
Severe
Textbook

Increased risk of gastritis, ulcer formation, and gastrointestinal bleeding. Glucocorticoids can also mask the symptoms of serious gastrointestinal disease, increasing the risk of perforated sigmoid diverticular abscesses.

Not explicitly stated, but implies caution and awareness of increased risk.

Source: G&G 14e · p1013

Diclofenac
Severe
Textbook

Increased risk of gastritis, ulcer formation, and gastrointestinal bleeding. Glucocorticoids can also mask the symptoms of serious gastrointestinal disease, increasing the risk of perforated sigmoid diverticular abscesses.

Not explicitly stated, but implies caution and awareness of increased risk.

Source: G&G 14e · p1013

Etodolac
Severe
Textbook

Increased risk of gastritis, ulcer formation, and gastrointestinal bleeding. Glucocorticoids can also mask the symptoms of serious gastrointestinal disease, increasing the risk of perforated sigmoid diverticular abscesses.

Not explicitly stated, but implies caution and awareness of increased risk.

Source: G&G 14e · p1013

Etoricoxib
Severe
Textbook

Increased risk of gastritis, ulcer formation, and gastrointestinal bleeding. Glucocorticoids can also mask the symptoms of serious gastrointestinal disease, increasing the risk of perforated sigmoid diverticular abscesses.

Not explicitly stated, but implies caution and awareness of increased risk.

Source: G&G 14e · p1013

Flurbiprofen
Severe
Textbook

Increased risk of gastritis, ulcer formation, and gastrointestinal bleeding. Glucocorticoids can also mask the symptoms of serious gastrointestinal disease, increasing the risk of perforated sigmoid diverticular abscesses.

Not explicitly stated, but implies caution and awareness of increased risk.

Source: G&G 14e · p1013

Related guidelines

Other Corticosteroid drugs

Ask House about glucocorticoids

Continue into a citation-backed clinical answer with the drug context already attached.

Sources: KD Tripathi 7e·Verified: 2026-05-10 · House clinical team