Quinidine
Contraindicated
Textbook
Fatal ventricular arrhythmias.
Avoid coadministration or ensure strict potassium management.
Source: G&G 14e · p567
Drug reference
Hydroflumethiazide
Thiazide Diuretic · Diuretic
Also known as Saluron, Aldactide
Thiazide DiureticDiuretic
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
incl. contraindicated
PREGNANCY
Manufacturer advises caution—no
FDA category + note
Top interactionssee all 12 →
- QuinidineContraindicatedTextbookG&G 14e · p567
- LithiumSevereTextbookG&G 14e · p378
- Aminolevulinic AcidSevereDatabaseDDInter
- AmiodaroneSevereDatabaseDDInter
Mechanism
Hydroflumethiazide is a thiazide diuretic that acts as an inhibitor of the Na+-Cl– symporter (ENCCl or TSC). This symporter is predominantly expressed in the kidney and localized to the apical membrane of distal convoluted tubule (DCT) epithelial cells. By inhibiting this symporter, Hydroflumethiazide reduces sodium and chloride reabsorption, leading to increased excretion of water, sodium, and chloride.
Indications
As a component of combination therapy for congestive heart failure
Dosing
- Adult
- ▶ BY MOUTH ▶ Adult: Initially 100/100 mg daily; maintenance 25/25–200/200 mg daily, maintenance dose not recommended because spironolactone generally given in lower dose → Appendix 1: aldosterone antagonists . thiazide diuretics l LESS SUITABLE FOR PRESCRIBING Co-flumactone tablets are less suitable for prescribing.…
Pharmacokinetics
Half-life
~17 hours
Bioavailability
~50%
Metabolism
20-60%
Excretion
Renal excretion of intact drug (40-80%) and metabolism (20-60%)
Side effects
Common
HypotensionHypokalemiaHyponatremia
Serious
- Severe hypokalemia
- Severe hyponatremia
Pregnancy & lactation
Pregnancy
Manufacturer advises caution—no
Drug interactions
Lithium
Severe
Textbook
Increased lithium levels and risk of toxicity.
Must be avoided.
Source: G&G 14e · p378
Aminolevulinic Acid
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amiodarone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Arsenic Trioxide
Severe
Database
Fatal ventricular arrhythmias.
Avoid coadministration or ensure strict potassium management.
Source: DDInter
Cisapride
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Dofetilide
Severe
Database
Fatal ventricular arrhythmias.
Avoid coadministration or ensure strict potassium management.
Source: DDInter
Dolasetron
Severe
Database
Clinical effect not specified
Source: DDInter
Dronedarone
Severe
Database
Clinical effect not specified
Source: DDInter
Droperidol
Severe
Database
Clinical effect not specified
Source: DDInter
Lithium Carbonate
Severe
Database
Clinical effect not specified
Source: DDInter
Pimozide
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Other Thiazide Diuretic drugs
Ask House about Hydroflumethiazide
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: BNF·Verified: 2026-05-13 · House clinical team