Mometasone Furoate

Mometasone furoate is a synthetic chlorinated corticosteroid with potent glucocorticoid receptor binding affinity and negligible mineralocorticoid activity. When applied topically or inhaled, it suppresses inflammatory gene transcription (NF-κB, AP-1) and upregulates anti-inflammatory proteins in target tissues with minimal systemic bioavailability (<1% for intranasal formulation). Its furoate ester confers high lipophilicity and prolonged tissue retention, enabling once-daily dosing for allergic rhinitis and asthma.

Pediatric

For severe atopic eczema on the limbs, a potent corticosteroid (e.g., mometasone furoate 0.1%) may be appropriate for 1–2 weeks only, then switch to a less potent preparation as the condition improves.