Drug reference

Triamcinolone

Corticosteroid · Anti-inflammatory

Also known as Triamcinolone acetonide

CorticosteroidAnti-inflammatory

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

12 major

SEVERE in our sources

PREGNANCY

—

not curated

Top interactionssee all 12 →

AdalimumabSevereDatabaseDDInter
AmprenavirSevereDatabaseDDInter
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Mechanism

Triamcinolone exerts predominantly glucocorticoid effects with minimal mineralcorticoid effect. It acts by suppressing inflammatory and allergic responses through its glucocorticoid activity.

Indications

Suppression of inflammatory and allergic disordersImmunosuppressionRheumatic diseasesEye inflammationOtitis externaAllergic rhinitisAphthous ulcersPalliative Carerheumatoid arthritis (intra-articular injection)nasaltopicaltemporary therapy for acute flare-ups of Crohn’s disease and ulcerative colitisocular inflammationocular surgeryuveitisinflammatory disordersimmunological disorders

Dosing

Adult: 40 mg (max. per dose 100 mg) by deep intramuscular injection into the gluteal muscle for depot effect, repeated if necessary.
Max dose: 100 mg per dose (intramuscular)

Pharmacokinetics

Duration

intermediate (12–36 h)

Half-life

Plasma t1/2 is 3 to 5 h, but the receptor-bound drug within responsive cells prolongs the half-life of effectiveness to ~36 h.

Bioavailability

High (90%) when taken orally.

Contraindications

peptic ulcer
diabetes mellitus
hypertension
viral infections
fungal infections
tuberculosis
other infections
osteoporosis
herpes simplex keratitis
psychosis
epilepsy
congestive heart failure
renal failure

Side effects

Common

HypertensionSodium retentionWater retentionPotassium lossCalcium lossDiabetesOsteoporosisMuscle wasting (proximal myopathy)Peptic ulcerationPsychiatric reactions

Serious