Buprenorphine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
Brivaracetam
Antiepileptic
Also known as Briviact
Antiepileptic
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
4 major
SEVERE in our sources
PREGNANCY
Women of child-bearing potential should discuss with a
FDA category + note
Top interactions
- BuprenorphineSevereDatabaseDDInter
- DextropropoxypheneSevereDatabaseDDInter
- RifampicinSevereDatabaseDDInter
- Sodium OxybateSevereDatabaseDDInter
Mechanism
Brivaracetam acts on synaptic vesicle glycoprotein 2A (SV2A). It is listed as targeting SV2A in the molecular targets of antiseizure drugs.
Indications
EpilepsySeizures
Dosing
- Adult
- Initially 25-50 mg BD, adjusted to response. Usual maintenance: 25-100 mg BD.
- Max dose
- 200 mg daily (100 mg BD)
Pregnancy & lactation
Pregnancy
Women of child-bearing potential should discuss with a
Drug interactions
Dextropropoxyphene
Severe
Database
Drug interaction classified as: synergy, metabolism
Source: DDInter
Rifampicin
Severe
Database
Decreased plasma concentrations of brivaracetam, potentially leading to reduced efficacy and increased seizure frequency.
Monitor brivaracetam plasma concentrations and/or clinical response (seizure control) when co-administering with rifampicin. A dose increase of brivaracetam may be necessary. Monitor for signs of reduced efficacy.
Source: DDInter
Sodium Oxybate
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
8 additional unreviewed or low-confidence interactions hidden because their provenance or source detail is insufficient.
Related guidelines
Initial monotherapy for newly diagnosed epilepsy
ILAE · Neurology · 2013
Functional (psychogenic non-epileptic) seizures
AAN · Neurology · 2026
Initial monotherapy for newly diagnosed epilepsy
IAN · Neurology · 2023
Status epilepticus
AAN · Neurology · 2020
Painful diabetic peripheral neuropathy
AAN · Neurology · 2022
Other Antiepileptic drugs
Ask House about Brivaracetam
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Textbook-sourced·Sources: Goodman & Gilman 14e, BNF·Updated: 2026-05-10