Drug reference

Brivaracetam

Antiepileptic

Also known as Briviact

Antiepileptic

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

4 major

SEVERE in our sources

PREGNANCY

Women of child-bearing potential should discuss with a

FDA category + note

Top interactionssee all 6 →

BuprenorphineSevereDatabaseDDInter
DextropropoxypheneSevereDatabaseDDInter
RifampicinSevereDatabaseDDInter
Sodium OxybateSevereDatabaseDDInter

Mechanism

Brivaracetam acts on synaptic vesicle glycoprotein 2A (SV2A). It is listed as targeting SV2A in the molecular targets of antiseizure drugs.

Indications

EpilepsySeizures

Dosing

Adult: Initially 25-50 mg BD, adjusted to response. Usual maintenance: 25-100 mg BD.
Max dose: 200 mg daily (100 mg BD)

Pregnancy & lactation

Pregnancy

Women of child-bearing potential should discuss with a

Drug interactions

Buprenorphine

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Dextropropoxyphene

Severe

Database

Drug interaction classified as: synergy, metabolism

Source: DDInter

Rifampicin

Severe

Database

Decreased plasma concentrations of brivaracetam, potentially leading to reduced efficacy and increased seizure frequency.

Monitor brivaracetam plasma concentrations and/or clinical response (seizure control) when co-administering with rifampicin. A dose increase of brivaracetam may be necessary. Monitor for signs of reduced efficacy.

Source: DDInter

Sodium Oxybate

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Alcohol

Moderate

Database

Increased risk of CNS adverse effects such as somnolence, dizziness, and ataxia.

Advise patients to avoid or limit alcohol consumption while taking brivaracetam due to the potential for additive CNS depression.

Other Cns Depressants (e.g., Benzodiazepines, Opioids, Tricyclic Antidepressants)

Moderate

Database

Increased risk of CNS adverse effects such as somnolence, dizziness, and ataxia.

Use with caution. Monitor patients for increased CNS depression. Consider dose adjustments of either brivaracetam or the co-administered CNS depressant if excessive sedation occurs.

6 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.