Ceftaroline fosamil

Ceftaroline fosamil, a cephalosporin antibiotic, exhibits pharmacology similar to penicillins, acting as a beta-lactam to inhibit bacterial cell wall synthesis. It specifically targets penicillin-binding proteins (PBPs), which are enzymes crucial for the transpeptidation step in peptidoglycan cross-linking. This interference compromises the structural integrity of the bacterial cell wall, leading to osmotic instability and subsequent cell lysis.

Adult

600 mg IV Q8-12 hr

Pediatric

Infant <2 months (ABSSSI indication only): 6 mg/kg/dose IV Q8 hr; 2 months to <2 years: 8 mg/kg/dose IV Q8 hr; 2 years to <18 years and ≤33 kg: 12 mg/kg/dose IV Q8 hr; 2 years to <18 years and >33 kg: 400 mg IV Q8 hr or 600 mg IV Q12 hr; Child ≥6 years and adolescent (Cystic fibrosis): 15 mg/kg/dose IV Q8 hr infused over 2 hr

Renal adjustment

100% of normal dose if creatinine clearance >30 mL/min. 50% of normal dose if creatinine clearance approximately 10 mL/min.

Max dose

600 mg/dose (pediatric cystic fibrosis)

• Immediate hypersensitivity to penicillin