fluticasone furoate

Corticosteroids enter target cells and bind to glucocorticoid receptors (GRs) in the cytoplasm. The steroid-GR complex moves into the nucleus, binding to specific DNA sequences to increase or decrease gene transcription, or interacting with protein transcription factors (e.g., AP-1, NF-κB) and coactivators. This suppresses inflammation by inhibiting inflammatory genes, preventing inflammatory cell recruitment, inhibiting cytokine formation, decreasing eosinophil survival, preventing vascular permeability, and inhibiting mucus secretion.