fluticasone propionate

Corticosteroids enter target cells and bind to glucocorticoid receptors (GRs) in the cytoplasm. The steroid-GR complex moves into the nucleus, binding to specific DNA sequences to increase or decrease gene transcription, or interacting with protein transcription factors (e.g., AP-1, NF-κB) and coactivators. This suppresses inflammation by inhibiting inflammatory genes, preventing inflammatory cell recruitment, inhibiting cytokine formation, decreasing eosinophil survival, preventing vascular permeability, and inhibiting mucus secretion.

Adult

100–250 µg BD (max 1000 µg/day) by inhalation