Drug reference

Norethisterone

Progestogen · Hormone Replacement Therapy, Contraceptive, Gynaecological disorder treatment, Antineoplastic agent

ProgestogenHormone Replacement Therapy, Contraceptive, Gynaecological disorder treatment, Antineoplastic agent

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

12 major

SEVERE in our sources

PREGNANCY

—

not curated

Top interactionssee all 12 →

AmoxicillinSevereTextbook-citedKDT 7e · p948
AmpicillinSevereTextbook-citedKDT 7e · p948
CarbamazepineSevereTextbook-citedKDT 7e · p949
CotrimoxazoleSevereTextbook-citedKDT 7e · p948

Mechanism

Norethisterone is a progestogen and a testosterone analogue. In hormone replacement therapy, it is added to long-term oestrogen therapy in women with an intact uterus to prevent cystic hyperplasia of the endometrium and possible transformation to cancer. For endometriosis, which is an oestrogen-dependent condition, it is administered to manage the condition.

Indications

Endometriosis (administered on a continuous basis)Menorrhagia (heavy menstrual bleeding) - note: relatively ineffective compared with tranexamic acid or mefenamic acidSevere dysmenorrhoea - note: for younger women requiring contraception, a combined oral contraceptive is the best choiceAlleviation of premenstrual symptoms (note: no convincing physiological basis for such treatment has been shown)Prevention of miscarriage in women with a history of recurrent miscarriage (note: no evidence of benefit and not recommended for this purpose)Hormone replacement therapy (as an add-on to long-term oestrogen therapy in women with a uterus, to prevent cystic hyperplasia of the endometrium and possible transformation to cancer; can be added on a cyclical or continuous basis)Combined oral contraceptivesProgestogen-only contraceptivesNeoplastic disease

Dosing

Adult: concentration of 10.2 g/100 mL (102 g/litre) or less. If the. haemoglobin concentration is more than 10.2 g/100 mL. (102 g/litre), ulipristal acetate may be considered. The use of. excessive menstrual blood loss of 80 mL or more, or for a

Contraindications

First time or getting progressively worse or sudden partial or complete loss of vision
Sudden disturbance of hearing or other perceptual disorders
Dysphasia
Bad fainting attack or collapse
First unexplained epileptic seizure
Weakness, motor disturbances, very marked numbness suddenly affecting one side or one part of body
Hepatitis, jaundice, liver enlargement
Blood pressure above systolic 160 mmHg or diastolic 95 mmHg
Prolonged immobility after surgery or leg injury
Detection of a risk factor which contra-indicates treatment