Buprenorphine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
Perampanel
Antiepileptic · Treatment of Epilepsy
AntiepilepticTreatment of Epilepsy
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
2 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 9 →
- BuprenorphineSevereDatabaseDDInter
- Sodium OxybateSevereDatabaseDDInter
Mechanism
Perampanel acts as a non-competitive antagonist at postsynaptic AMPA receptors. By selectively blocking glutamate activity at these excitatory synapses, it reduces neuronal hyperexcitability. This mechanism helps to prevent the occurrence of seizures.
Indications
Epilepsy and other seizure disorders
Dosing
- Adult
- Careful adjustment of doses is necessary, starting with low doses and increasing gradually until seizures are controlled or there are significant adverse effects. Can be given once daily at bedtime.
Pharmacokinetics
Half-life
long
Drug interactions
Sodium Oxybate
Severe
Database
Clinical effect not specified
Source: DDInter
Progesterone Containing Contraceptives
Moderate
Textbook
Decreased effectiveness of progesterone-containing contraceptives.
Monitor for reduced efficacy.
Source: G&G 14e · p401
Carbamazepine
Moderate
Database
Decreased effectiveness of carbamazepine and decreased serum perampanel concentrations.
Monitor for reduced efficacy of carbamazepine and adjust perampanel dosing.
Source: DDInter
Clobazam
Moderate
Database
Decreased effectiveness of clobazam.
Monitor for reduced efficacy.
Source: DDInter
Lamotrigine
Moderate
Database
Decreased effectiveness of lamotrigine.
Monitor for reduced efficacy.
Source: DDInter
Oxcarbazepine
Moderate
Database
Decreased serum perampanel concentrations.
Adjust perampanel dosing.
Source: DDInter
Topiramate
Moderate
Database
Decreased serum perampanel concentrations.
Adjust perampanel dosing.
Source: DDInter
Valproic Acid
Moderate
Database
Decreased effectiveness of valproic acid.
Monitor for reduced efficacy.
Source: DDInter
3 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
Initial monotherapy for newly diagnosed epilepsy
IAN · Neurology · 2023
Initial monotherapy for newly diagnosed epilepsy
ILAE · Neurology · 2013
Functional (psychogenic non-epileptic) seizures
AAN · Neurology · 2026
Status epilepticus
AAN · Neurology · 2020
Hypertensive disorders of pregnancy
FOGSI · Obstetrics & Gynaecology · 2019
Other Antiepileptic drugs
Ask House about Perampanel
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, Katzung, BNF·Verified: 2026-05-10 · House clinical team