Vigabatrin

Vigabatrin (γ-vinyl-GABA) is an irreversible inhibitor of GABA transaminase (GABA-T), the enzyme responsible for the metabolic degradation of GABA. By permanently inactivating GABA-T through covalent binding to its catalytic site, vigabatrin causes sustained elevation of brain GABA levels (2-4 fold increase) that persists until new enzyme is synthesized. Its use is restricted to infantile spasms (West syndrome) and refractory complex partial seizures due to the risk of irreversible bilateral visual field defects from retinal toxicity affecting approximately 30-40% of patients.

Adult

complex partial (CP) seizures in a dose of 60 mg discharge and ‘aura’ persist.. 1–3 times a day in adults; in children (3–5 mg/. GARDENAL 30, 60 mg tabs, 20 mg/5 ml syr; LUMINAL of voltage sensitive neuronal Na+ channel (Fig.. 30 mg tab, PHENOBARBITONE SODIUM 200 mg/ml inj.. Dose: 250–500 mg BD, children 10–20 mg/kg/day. not interfere with kindling. Its ability to selec-

• Absence seizures or syndromes